个人简介
冀培丰，博导，北京大学第一医院组学技术中心主任，实验中心副主任。研究方向为前沿组学技术研究，包括：空间多组学相关的实验和算法开发、基于类器官的高通量药物筛选、人造器官。迄今以第一及通讯作者（共同）在Cell, Nature Methods, Genome Biology, Nature Communications, Genome Medicine, Cell Genomics, Nucleic Acids Research等国际学术刊物上发表研究论文16篇。研究成果入选“2023年度和2025年度中国生物信息学十大进展”和2025年“中国蛋白质组学十大进展”。中国生物物理学会肠道菌群分会委员。主持国自然项目3项，以课题负责人承担重点研发1项并参与2项，北京市高层次创新创业人才支持计划。
研究方向
1.空间组学技术开发：基于微流控、纳米材料、水凝胶等技术开发生物大分子空间原位检测技术。
2.基于AI的生物信息学算法开发：基于海量生物数据构建AI模型，发现和解析新生物学过程。
3. 器官制造：利用光、磁、声等调控技术，体外构建类器官。
学术成果
1.Ji, P.^, Wang, N^, Yu, Y^, Zhao, F.*. (2025). Single-cell delineation of the microbiota-gut-brain axis: probiotic intervention in Chd8 haploinsufficient mice. Cell Genomics, 5(2), 100768.
2.Hu, B.^, He, R.^, Pang, K.^, Wang, G.^, Wang, N., Zhu, W., Sui, X, Teng, H., Liu, T., Zhu, J, Jiang, Z., Zhang, J., Zuo, Z., Wang, W., Ji, P.*, Zhao, F.*. (2025). High-resolution spatially resolved proteomics for complex tissues based on microfluidics and transfer learning. Cell, 188(3):734-748.
3.He, R.^, Zhu, J.^, Ji, P.*, Zhao, F.*. (2024). SEVtras delineates small extracellular vesicles at droplet resolution from single-cell transcriptomes. Nat Methods 21, 259-266.
4.Zhang, F., Fan, Y, Phung, N., Ji, B., Chen, J., Xu, X., Li, F.*, Ji, P.*, Yang, H.*, Li, X.*. (2024) Nervonic acid alleviates stroke and its associated poststroke depression behaviors. hLife 11, 592-606.
5.An, N.^, Yang, F.^, Zhang, G., Jiang, Y., Liu, H., Gao, Y., Li, Y., Ji, P.*, Shang, H.*, Xing, Y.*. (2024) Single-cell RNA sequencing reveals the contribution of smooth muscle cells and endothelial cells to fibrosis in human atrial tissue with atrial fibrillation. Molecular Medicine 30, 240.
6.Yu, Y. ^, Zhang, B.^, Ji, P.^, Zuo, Z., Huang, Y., Wang, N., Liu, C., Liu, S.J., and Zhao, F.*. (2022). Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Nat Commun 13, 1151.
7.Wu, W.^, Ji, P.^, Zhao, F.*. (2020). CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes. Genome Biol 21, 101.
8.Zheng, Y.,^ Ji, P.^, Chen, S.^, Hou, L., Zhao, F.*. (2019). Reconstruction of full-length circular RNAs enables isoform-level quantification. Genome Med 11, 2.
9.Ji, P.^, Wu, W.^, Chen, S.^, Zheng, Y., Zhou, L., Zhang, J., Cheng, H., Yan, J., Zhang, S., Yang, P., Zhao, F.*. (2019). Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals. Cell Rep 26, 3444-3460 e3445.
10.Shi, W.^, Ji, P.^, Zhao, F.*. (2017). The combination of direct and paired link graphs can boost repetitive genome assembly. Nucleic Acids Res 45, e43.
11.Ji, P. ^, Zhang, Y.^, Wang, J., Zhao, F.*. (2017). MetaSort untangles metagenome assembly by reducing microbial community complexity. Nat Commun 8, 14306.
